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A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Preliminary Study for the Region of Norte de Santander (Colombia)

Contreras Ropero, Jefferson Eduardo; Ruiz Roa, Silvia Liliana; García-Martinez, Janet; Urbina-Suarez, Nestor Andres; López Barrera, German Luciano; Barajas Solano, andres F; ZUORRO, Antonio (Applied Sciences (Switzerland), 2021-12-24)

The production of vaccines of biological origin presents a tremendous challenge for researchers. In this context, animal cell cultures are an excellent alternative for the isolation and production of biologicals against ...
Using the Response Surface Methodology to Treat Tannery Wastewater with the Bicarbonate-Peroxide System

Urbina-Suarez, Nestor Andres; Salcedo Pabón, Cristian Jesús; López Barrera, German Luciano; García-Martinez, Janet; Barajas Solano, andres F; Machuca-Martínez, Fiderman (ChemEngineering, 2023-07-16)

A bicarbonate-peroxide (BAP) system was evaluated to improve the quality of industrial tannery wastewater using an I-optimal experimental design with four variables (temperature, initial pH, bicarbonate, and H2O2 concentration). ...

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A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Preliminary Study for the Region of Norte de Santander (Colombia)
...
Contreras Ropero, Jefferson Eduardo | 2021-12-24

The production of vaccines of biological origin presents a tremendous challenge for researchers. In this context, animal cell cultures are an excellent alternative for the isolation and production of biologicals against several viruses, since they have an affinity with viruses and a great capacity for their replicability. Different variables have been studied to know the system’s ideal parameters, allowing it to obtain profitable and competitive products. Consequently, this work focuses its efforts on evaluating an alternative for producing an anti-influenza biological from MDCK cells using SuperPro Designer v8.0 software. The process uses the DMEN culture medium supplemented with nutrients as raw material for cell development; the MDCK cells were obtained from a potential scale-up with a final working volume of 500 L, four days of residence time, inoculum volume of 10%, and continuous working mode with up to a total of 7400 h/Yr of work. The scheme has the necessary equipment for the vaccine’s production, infection, and manufacture with yields of up to 416,698 units/h. In addition, it was estimated to be economically viable to produce recombinant vaccines with competitive prices of up to 0.31 USD/unit.

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Using the Response Surface Methodology to Treat Tannery Wastewater with the Bicarbonate-Peroxide System
...
Urbina-Suarez, Nestor Andres | 2023-07-16

A bicarbonate-peroxide (BAP) system was evaluated to improve the quality of industrial tannery wastewater using an I-optimal experimental design with four variables (temperature, initial pH, bicarbonate, and H2O2 concentration). The response variables were COD removal, ammonia nitrogen removal, and nitrate concentration. The most critical variables were optimized using a The process was carried out in 500 mL reactors, the operational volume of 250 mL, and the agitation was at 550 rpm. A new I-optimal reaction surface design at two levels (bicarbonate concentration 0.01–0.3 mol/L and H2O2 0.05–0.35 mol/L) was used to obtain the optimal data of the experimental design. Optimal conditions were validated by one-way ANOVA statistical analysis using Prism software. Temperatures above 50 °C promote the efficiency of the BAP system, and slightly acidic initial pHs allow stabilization of the system upon inclusion of bicarbonate and peroxide in the concentration of bicarbonate, which is critical for the reaction with peroxide and formation of reactive oxygen species. With the validated optimal data, removal percentages above 78% were achieved for nitrites, ammonia nitrogen, chromium, TSS, BOD, conductivity, chromium, and chlorides; for COD and TOC, removal percentages were above 45%, these results being equal and even higher than other AOPs implemented for this type of water.

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Listar Grupo de Investigación en Ingeniería Ambiental - GRIAMB por autor "80edb67ba4cf51c8ef0d2bf62e0faa4d"

A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Preliminary Study for the Region of Norte de Santander (Colombia)

Using the Response Surface Methodology to Treat Tannery Wastewater with the Bicarbonate-Peroxide System

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A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Preliminary Study for the Region of Norte de Santander (Colombia)

Using the Response Surface Methodology to Treat Tannery Wastewater with the Bicarbonate-Peroxide System

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Listar Grupo de Investigación en Ingeniería Ambiental - GRIAMB por autor "80edb67ba4cf51c8ef0d2bf62e0faa4d"

A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Preliminary Study for the Region of Norte de Santander (Colombia) ﻿

Using the Response Surface Methodology to Treat Tannery Wastewater with the Bicarbonate-Peroxide System ﻿

Envíos recientes

A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Preliminary Study for the Region of Norte de Santander (Colombia)

Using the Response Surface Methodology to Treat Tannery Wastewater with the Bicarbonate-Peroxide System

Portales Institucionales

A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Preliminary Study for the Region of Norte de Santander (Colombia)

Using the Response Surface Methodology to Treat Tannery Wastewater with the Bicarbonate-Peroxide System