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Grupo de Investigación en Ingeniería Ambiental - GRIAMB

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A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Preliminary Study for the Region of Norte de Santander (Colombia)

Contreras Ropero, Jefferson Eduardo | 2021-12-24

The production of vaccines of biological origin presents a tremendous challenge for researchers. In this context, animal cell cultures are an excellent alternative for the isolation and production of biologicals against several viruses, since they have an affinity with viruses and a great capacity for their replicability. Different variables have been studied to know the system’s ideal parameters, allowing it to obtain profitable and competitive products. Consequently, this work focuses its efforts on evaluating an alternative for producing an anti-influenza biological from MDCK cells using SuperPro Designer v8.0 software. The process uses the DMEN culture medium supplemented with nutrients as raw material for cell development; the MDCK cells were obtained from a potential scale-up with a final working volume of 500 L, four days of residence time, inoculum volume of 10%, and continuous working mode with up to a total of 7400 h/Yr of work. The scheme has the necessary equipment for the vaccine’s production, infection, and manufacture with yields of up to 416,698 units/h. In addition, it was estimated to be economically viable to produce recombinant vaccines with competitive prices of up to 0.31 USD/unit.

S-curve and landscape maps for the analysis of trends on industrial textile wastewater treatment

Urbina-Suarez, Nestor Andres | 2024-01-18

The textile industry is one of the most important and economically significant industries in the world. China is the largest textile producer, for countries such as India, Pakistan, Bangladesh and Malaysia this sector is of crucial importance and it is also a growing sector in Latin America. This industry is responsible for 10 % of annual global carbon emissions and 20 % of global wastewater. This figure is worrying as this wastewater is highly recalcitrant, which has led to research into different treatment methods that are efficient and can provide a sustainable solution to this problem. The aim of this literature review was to identify the existing methods for the treatment of dry scrubber wastewater (TWWT) and the effects of this wastewater and its composition, focusing on biological, chemical and physicochemical processes from the point of view of advantages and disadvantages. It was analyzed which are the most important scientific areas of TWWT and which countries are the most important in this field, as well as the primary pollutants and TWWT processes. Finally, this analysis provides a context for current trends in TWWT research. In general, coagulation methods have been found to be fast but present difficulties due to the use of toxic coagulants; advanced oxidation processes (AOPs) are positioned as very effective methods that can disinfect and decontaminate these effluents. Currently, biological systems coupled with AOPs are a growing trend. Microalgae and cyanobacteria processes coupled with AOPs have attracted great interest due to the possibility of obtaining high added value products through the biorefining of biomass.

Bicarbonate-Hydrogen Peroxide System for Treating Dyeing Wastewater: Degradation of Organic Pollutants and Color Removal

Urbina-Suarez, Nestor Andres | 2023-04-11

: The textile industry is a global economic driving force; however, it is also one of the most polluting industries, with highly toxic effluents which are complex to treat due to the recalcitrant nature of some compounds present in these effluents. This research focuses on the removal of Chemical Oxygen Demand (COD), color, Total Organic Carbon (TOC), and Ammoniacal Nitrogen (N-NH3 ) on tannery wastewater treatment through an advanced oxidation process (AOPs) using sodium bicarbonate (NaHCO3 ), hydrogen peroxide (H2O2 ) and temperature using a central composite non-factorial design with a surface response using Statistica 7.0 software. All experiments used a 500 mL reactor with 300 mL of tannery wastewater from a company in Cúcuta, Colombia. The physicochemical characterization was done to determine the significant absorbance peaks about the color in the wavelengths between 297 and 669 nm. Statistical analysis found that the concentration of NaHCO3 affects the removal of color and N-NH3 ; however, it did not affect COD and TOC. The optimal process conditions for removing the different compounds under study were: NaHCO3 1 M, H2O2 2 M, and 60 ◦C, with efficiencies of 92.35%, 31.93%, 68.85%, and 35.5% N-NH3 , COD, color, and TOC respectively. It can be concluded that AOPs using H2O2 and NaHCO3 are recommended to remove color and N-NH3.

Using the Response Surface Methodology to Treat Tannery Wastewater with the Bicarbonate-Peroxide System

Urbina-Suarez, Nestor Andres | 2023-07-16

A bicarbonate-peroxide (BAP) system was evaluated to improve the quality of industrial tannery wastewater using an I-optimal experimental design with four variables (temperature, initial pH, bicarbonate, and H2O2 concentration). The response variables were COD removal, ammonia nitrogen removal, and nitrate concentration. The most critical variables were optimized using a The process was carried out in 500 mL reactors, the operational volume of 250 mL, and the agitation was at 550 rpm. A new I-optimal reaction surface design at two levels (bicarbonate concentration 0.01–0.3 mol/L and H2O2 0.05–0.35 mol/L) was used to obtain the optimal data of the experimental design. Optimal conditions were validated by one-way ANOVA statistical analysis using Prism software. Temperatures above 50 °C promote the efficiency of the BAP system, and slightly acidic initial pHs allow stabilization of the system upon inclusion of bicarbonate and peroxide in the concentration of bicarbonate, which is critical for the reaction with peroxide and formation of reactive oxygen species. With the validated optimal data, removal percentages above 78% were achieved for nitrites, ammonia nitrogen, chromium, TSS, BOD, conductivity, chromium, and chlorides; for COD and TOC, removal percentages were above 45%, these results being equal and even higher than other AOPs implemented for this type of water.