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Caracterización molecular y detección de genes blaCTX-M grupos 1 y 9 en Klebsiella pneumoniae resistentes a ceftazidima, en un hospital de San José de Cúcuta, Colombia

dc.contributor.authorGalvis, Fabian
dc.contributor.authorMoreno Rozo, laura Yolima
dc.date.accessioned2021-12-09T20:41:04Z
dc.date.available2021-12-09T20:41:04Z
dc.date.issued2019-06
dc.identifier.urihttp://repositorio.ufps.edu.co/handle/ufps/1781
dc.description.abstractBackground: The expression of CTX-M β-lactamases belonging to groups 1 and 9 in Klebsiella pneumoniae produces high levels of resistance to ceftazidime, and they have a wide distribution worldwide. Aim: To identify and characterize the blaCTX-M-Group1 and blaCTX-M-Group9 genes in K. pneumoniae isolates resistant to ceftazidime in a hospital in San José de Cúcuta, Colombia. Material and Methods: Primers were designed for the identification of K. pneumoniae and blaCTX-M genes by PCR. Subsequently, the genetic relationship of these isolates was analyzed by REP-PCR. Results: A 38% of the 24 isolates identified by PCR as K. pneumoniae showed blaCTX-M-3. blaCTX-M-15 y blaCTX-M-32 genes (Group CTX-M-1) and 42% blaCTX-M14. blaCTX-M-24 y blaCTX-M-27 genes (Group CTX-M-9). The phylogenetic analysis grouped the K. pneumoniae isolates into 4 clusters, showing correlation in clusters I, II and IV, when comparing the genetic profiles with the type of sample and group of genes. Discussion: We found a similar frequency of blaCTX-M-Group 1 and blaCTX-M-Group 9 genes in isolates of K. pneumoniae resistant to ceftazidime. The correlation between the REP-PCR with the CTX-M groups and the type of sample revealed the presence of three clonal patterneng
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherRevista Chilena de Infectologiaspa
dc.relation.ispartofRevista chilena de infectología
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly citedeng
dc.sourcehttps://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182019000300304&lng=en&nrm=iso&tlng=enspa
dc.titleCaracterización molecular y detección de genes blaCTX-M grupos 1 y 9 en Klebsiella pneumoniae resistentes a ceftazidima, en un hospital de San José de Cúcuta, Colombiaeng
dc.typeArtículo de revistaspa
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dc.coverage.citySan Jose De Cùcuta , Colombia
dc.identifier.doihttp://dx.doi.org/10.4067/S0716-10182019000300304
dc.publisher.placeSantiago de Chile , Chilespa
dc.relation.citationeditionVol.36 No.3.(2019)spa
dc.relation.citationendpage311spa
dc.relation.citationissue3 (2019)spa
dc.relation.citationstartpage304spa
dc.relation.citationvolume36spa
dc.relation.citesGalvis, F., & Moreno, L. (2019). Caracterización molecular y detección de genes blaCTX-M grupos 1 y 9 en Klebsiella pneumoniae resistentes a ceftazidima, en un hospital de San José de Cúcuta, Colombia. Revista chilena de infectología, 36(3), 304-311.
dc.relation.ispartofjournalMolecular characterization and detection of genes blaCTX-M groups 1 and 9 in Klebsiella pneumoniae resistant to ceftazidime, in a hospital in San José de Cúcuta, Colombiaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.subject.proposalblaCTX-Mspa
dc.subject.proposalceftazidimaspa
dc.subject.proposalKlebsiella pneumoniaeeng
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa


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