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Simulating of Microbial Growth Scale Up in a Stirred Tank Bioreactor for Aerobic Processes using Computational Fluid Dynamics
| dc.contributor.author | Gelves, German | |
| dc.contributor.author | Niño, Lilibeth | |
| dc.contributor.author | Hernandez, S | |
| dc.date.accessioned | 2021-11-27T16:42:09Z | |
| dc.date.available | 2021-11-27T16:42:09Z | |
| dc.date.issued | 2020-11-04 | |
| dc.identifier.uri | http://repositorio.ufps.edu.co/handle/ufps/1496 | |
| dc.description.abstract | In this paper, the effects of some empirical scale up criteria (Reynold´s number and Impeller power per bioreactor volume) on gas-liquid mass transfer and microbial growth rates are analyzed using computational fluid dynamics simulations in a stirred tank bioreactor. The effects of turbulence, fluid flow and bubbles dynamics were simulated by using a two equation turbulence model, a multiple reference frame and a population balance, respectively. The impeller power per bioreactor volume scale up criterion showed better microbial growth rates than Reynold´s number scale up criterion. However, high cellular damage due to turbulence in animal cell culturing are still challenges in large scale up bioreactor prototyping. | eng |
| dc.format.extent | 6 páginas | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.language.iso | eng | spa |
| dc.publisher | Journal of Physics: Conference Series | spa |
| dc.relation.ispartof | Journal of Physics: Conference Series ISSN: 1742-6596, 2020 vol:1655 fasc: N/A págs: 1 - 6, DOI:10.1088/1742-6596/1655/1/012109 | |
| dc.rights | Content from this work may be used under the terms of theCreative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Published under licence by IOP Publishing Ltd | eng |
| dc.source | https://iopscience.iop.org/article/10.1088/1742-6596/1655/1/012109 | spa |
| dc.title | Simulating of Microbial Growth Scale Up in a Stirred Tank Bioreactor for Aerobic Processes using Computational Fluid Dynamics | eng |
| dc.type | Artículo de revista | spa |
| dcterms.references | Niño L, Gelves R, Ali H, Solsvik J and Jakobsen H 2019 Applicability of a modified breakage and coalescence model based on the complete turbulence spectrum concept for CFD simulation of gas-liquid mass transfer in a stirred tank reactor Chemical Engineering Science 211 1 | spa |
| dcterms.references | Gelves R, Benavides A and Quintero J C F D 2013 prediction of hydrodynamic behavior in the scale-up of a stirred tank reactor for aerobic processes Ingeniare Revista Chilena de ingeniería 21 347 | spa |
| dcterms.references | Gelves G 2020 Simulating hydrodynamics in a Rushton turbine at different stirring velocities applied to non-Newtonian fluids Journal of Physics: Conference Series 1587 012012 | spa |
| dcterms.references | Rutherford K, Lee, Mahmoudi K and Yianneskis M 1996 Hydrodynamic characteristics of dual Rushton impeller stirred vessels American Intitute of Chemical Engineering 42 332 | spa |
| dcterms.references | Kerdouss F, Bannari A, Proulx P, Bannari R, Skrga M and Labrecque Y 2012 Two-phase mass transfer coefficient prediction in a stirred vessel with a CFD model Computers and Chemical Engineering 32 1943 | spa |
| dcterms.references | Luo J, Issaand R and Gosman A 1994 Prediction of impeller induced flow in mixing vessels using multiple frames of reference Chemical Engineering Symposium Series. Institution of Chemical Engineers 136 549 | spa |
| dcterms.references | Micale G, Brucato and A Grisafi F 1999 Prediction of flow fields in a dual-impeller stirred tank American Intitute of Chemical Engineering 45(3) 445 | spa |
| dcterms.references | Tabor A, Gosman G and Issa R 1996 Numerical simulation of the flow in a mixing vessel stirred by a Rushton Turbine American Intitute of Chemical Engineering Symposium Series 140 25 | spa |
| dcterms.references | Solsvik J and Jakobsen H 2016 A review of the statistical turbulence theory required extending the population balance closure models to the entire spectrum of turbulence American Intitute of Chemical Engineering 62(5) 1795 | spa |
| dc.identifier.doi | 10.1088/1742-6596/1655/1/012109 | |
| dc.publisher.place | Reino Unido | spa |
| dc.relation.citationedition | Vol. 1655, 012109 (2020) | spa |
| dc.relation.citationendpage | 6 | spa |
| dc.relation.citationstartpage | 1 | spa |
| dc.relation.citationvolume | 1655 | spa |
| dc.relation.cites | Hernandez, S., Niño, L. y Gelves, G. (2020). Simulating of microbial growth scale up in a stirred tank bioreactor for aerobic processes using computational fluid dynamics. Journal of Physics: Conference Series, 1655, Artículo 012109. https://doi.org/10.1088/1742-6596/1655/1/012109 | |
| dc.relation.ispartofjournal | Journal of Physics: Conference Series | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.creativecommons | Atribución 4.0 Internacional (CC BY 4.0) | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
| dc.type.content | Text | spa |
| dc.type.driver | info:eu-repo/semantics/article | spa |
| dc.type.redcol | http://purl.org/redcol/resource_type/ART | spa |
| oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
| dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
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