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In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics

García-Páez, Ismael H.; de Aza, Antonio H.; Parra, Juan; Baudin, Carmen; Martín, M. Rocío; Pena, Pilar (Journal of Biomedical Materials Research Part AInglaterra, 2017-04-20)

The objective of this work was to study the feasibility of the solid state sintering, a conventional ceramic processing method, to obtain Mg and Si co-substituted tricalcium phosphate bioceramics and composites containing ...
Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition

García-Páez, Ismael H.; de Aza, Antonio H.; Peña, Pilar García; Baudin, Carmen; Córdoba Tuta, Elcy María; Rodríguez, Miguel A. (Boletín de la Sociedad Española de Cerámica y VidrioEspaña, 2016-02)

In this study, a dense bioactive ceramic, with nominal composition (wt.%) 40 Ca3(PO4)2–60 CaMg(SiO3)2, was prepared by solid state sintering of homogeneous compacted mixtures of fine synthetic Ca3(PO4)2 and CaMg(SiO3)2 ...

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In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics
...
García-Páez, Ismael H. | 2017-04-20

The objective of this work was to study the feasibility of the solid state sintering, a conventional ceramic processing method, to obtain Mg and Si co-substituted tricalcium phosphate bioceramics and composites containing diopside. A series of new Ca3(PO4)2 based ceramics has been prepared from attrition milled mixtures of synthetic Ca3(PO4)2 and CaMg(SiO3)2 powders, isostatically pressed and sintered at 1250–1300°C. Materials containing 0, 1, and 5 wt % of CaMg(SiO3)2 were constituted by β + α - Ca3(PO4)2 solid solutions while the material containing 60 wt % of CaMg(SiO3)2 was a constituted by β- Ca3(PO4)2 and CaMg(SiO3)2. The biological responses of the developed ceramics were studied in vitro using human fetal osteoblast cultures. Culture times ranged from 1 to 21 days. The new family of materials promotes the adhesion and proliferation of human osteoblasts cultured onto their surface forming a monolayer and showing a normal morphology. The results of the MTT and Alamar Blue assays showed that the soluble components extracted from the Mg/Si- co-substituted Ca3(PO4)2 and the Ca3(PO4)2-CaMg(SiO3)2 composite were noncytotoxic. The specimens with diopside exhibited a better in vitro behavior which is attributed to the release of Si and Mg ions to the culture medium, enhancing the activity of cells. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2266–2275, 2017.

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Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition
...
García-Páez, Ismael H. | 2016-02

In this study, a dense bioactive ceramic, with nominal composition (wt.%) 40 Ca3(PO4)2–60 CaMg(SiO3)2, was prepared by solid state sintering of homogeneous compacted mixtures of fine synthetic Ca3(PO4)2 and CaMg(SiO3)2 powders. The results obtained by X-ray diffraction and field emission scanning electron microscopy with microanalysis indicate that the ceramic composite showed a fine grained and homogeneous microstructure consisting of diopside (CaMg(SiO3)2) and whitlockite (-Ca3(PO4)2ss) grains with very small amounts of apatite. The flexural strength and elastic modulus values of the composite are similar to those of cortical human bone. Bioactivity was experimentally evaluated by examining in vitro apatite formation in simulated body fluid (SBF). In addition, a simulation of the dissolution properties of the different phases present in the material in SBF was carried out by thermodynamic calculations, with the purpose of understanding the in vitro results obtained. The experimental results demonstrated that, during soaking in SBF, the grains of whitlockite dissolved preferentially than those of diopside, leaving a porous surface layer rich in diopside. Subsequently, partial dissolution of the remaining diopside occurred and the porous surface of the ceramic became coated by a bone-like apatite layer after 7 days in SBF. This bioceramic containing -Ca3(PO4)2 and CaMg(SiO3)2 is expected to be useful to fabricate scaffolds for bone repair

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Listar Diseño Mecánico, Materiales y Procesos - GIDIMA por autor "d252036f5b13c0de5e9bedd2a9c80c2f"

In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics

Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition

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In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics

Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition

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Listar Diseño Mecánico, Materiales y Procesos - GIDIMA por autor "d252036f5b13c0de5e9bedd2a9c80c2f"

In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics ﻿

Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition ﻿

Envíos recientes

In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics

Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition

Portales Institucionales

In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics

Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition