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In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics

García-Páez, Ismael H.; de Aza, Antonio H.; Parra, Juan; Baudin, Carmen; Martín, M. Rocío; Pena, Pilar (Journal of Biomedical Materials Research Part AInglaterra, 2017-04-20)

The objective of this work was to study the feasibility of the solid state sintering, a conventional ceramic processing method, to obtain Mg and Si co-substituted tricalcium phosphate bioceramics and composites containing ...
Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition

García-Páez, Ismael H.; de Aza, Antonio H.; Peña, Pilar García; Baudin, Carmen; Córdoba Tuta, Elcy María; Rodríguez, Miguel A. (Boletín de la Sociedad Española de Cerámica y VidrioEspaña, 2016-02)

In this study, a dense bioactive ceramic, with nominal composition (wt.%) 40 Ca3(PO4)2–60 CaMg(SiO3)2, was prepared by solid state sintering of homogeneous compacted mixtures of fine synthetic Ca3(PO4)2 and CaMg(SiO3)2 ...
Síntesis en estado sólido y caracterización de fosfato tricálcico dopado con magnesio y zinc

García-Páez, Ismael H.; Ardila Melo, Reinaldo; Pinzón-Bedoya, Martha L. (Revista Latinoamericana de Metalurgia y MaterialesVenezuela, 2017-04-23)

El desarrollo de biocerámicas para aplicaciones estructurales está limitado debido a su baja tenacidad y resistencia. Estas limitaciones conllevan a investigaciones que buscan mejorar su rendimiento mecánico mediante dopado ...

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In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics
...
García-Páez, Ismael H. | 2017-04-20

The objective of this work was to study the feasibility of the solid state sintering, a conventional ceramic processing method, to obtain Mg and Si co-substituted tricalcium phosphate bioceramics and composites containing diopside. A series of new Ca3(PO4)2 based ceramics has been prepared from attrition milled mixtures of synthetic Ca3(PO4)2 and CaMg(SiO3)2 powders, isostatically pressed and sintered at 1250–1300°C. Materials containing 0, 1, and 5 wt % of CaMg(SiO3)2 were constituted by β + α - Ca3(PO4)2 solid solutions while the material containing 60 wt % of CaMg(SiO3)2 was a constituted by β- Ca3(PO4)2 and CaMg(SiO3)2. The biological responses of the developed ceramics were studied in vitro using human fetal osteoblast cultures. Culture times ranged from 1 to 21 days. The new family of materials promotes the adhesion and proliferation of human osteoblasts cultured onto their surface forming a monolayer and showing a normal morphology. The results of the MTT and Alamar Blue assays showed that the soluble components extracted from the Mg/Si- co-substituted Ca3(PO4)2 and the Ca3(PO4)2-CaMg(SiO3)2 composite were noncytotoxic. The specimens with diopside exhibited a better in vitro behavior which is attributed to the release of Si and Mg ions to the culture medium, enhancing the activity of cells. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2266–2275, 2017.

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Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition
...
García-Páez, Ismael H. | 2016-02

In this study, a dense bioactive ceramic, with nominal composition (wt.%) 40 Ca3(PO4)2–60 CaMg(SiO3)2, was prepared by solid state sintering of homogeneous compacted mixtures of fine synthetic Ca3(PO4)2 and CaMg(SiO3)2 powders. The results obtained by X-ray diffraction and field emission scanning electron microscopy with microanalysis indicate that the ceramic composite showed a fine grained and homogeneous microstructure consisting of diopside (CaMg(SiO3)2) and whitlockite (-Ca3(PO4)2ss) grains with very small amounts of apatite. The flexural strength and elastic modulus values of the composite are similar to those of cortical human bone. Bioactivity was experimentally evaluated by examining in vitro apatite formation in simulated body fluid (SBF). In addition, a simulation of the dissolution properties of the different phases present in the material in SBF was carried out by thermodynamic calculations, with the purpose of understanding the in vitro results obtained. The experimental results demonstrated that, during soaking in SBF, the grains of whitlockite dissolved preferentially than those of diopside, leaving a porous surface layer rich in diopside. Subsequently, partial dissolution of the remaining diopside occurred and the porous surface of the ceramic became coated by a bone-like apatite layer after 7 days in SBF. This bioceramic containing -Ca3(PO4)2 and CaMg(SiO3)2 is expected to be useful to fabricate scaffolds for bone repair

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Síntesis en estado sólido y caracterización de fosfato tricálcico dopado con magnesio y zinc
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García-Páez, Ismael H. | 2017-04-23

El desarrollo de biocerámicas para aplicaciones estructurales está limitado debido a su baja tenacidad y resistencia. Estas limitaciones conllevan a investigaciones que buscan mejorar su rendimiento mecánico mediante dopado con elementos similares a los presentes en el hueso humano y a materiales que no generen reacciones o toxicidad, tales como: CO32--, SiO44- , Mg2+, Zn2+, F-, Cl-, Ag+, Na+ y K+. Dentro de este contexto, la presente investigación fue enfocada a la síntesis de fosfato tricálcico (TCP) dopado con iones magnesio Mg+ y zinc Zn+, mediante sinterización en estado sólido. La adición de los dopantes se realizó en forma de óxidos, así: M-1(1 wt% Mg, 1wt% Zn), M-4 (4 wt% Mg, 1 wt% Zn) y M-7 (7 wt% Mg, 1 wt% Zn), mediante mezcla y calcinación de las materias primas a 900 °C y posterior sinterización a 1200, 1300 y 1400 °C. La caracterización microestructural se realizó mediante Microscopía Electrónica de Barrido, MEB, y la composicional mediante difracción de rayos X, DRX y espectrometría de energía dispersiva, EDX. Se determinó que la fase mayoritaria en todos los casos fue β-TCP y que el cambio de la faseβ→α-TCP solo se presentó en la muestra M-7 sinterizada a 1400°C. Adicionalmente, se realizó un estudio del comportamiento in vitro en suero fisiológico artificial (SFA), donde se observó baja formación de apatita en la superficie durante la inmersión de 28 días. Finalmente, se realizó un estudio mecánico mediante el ensayo de compresión diametral en probetas de disco de diámetro 10,0 ± 0,3 mm y espesor 2,8 ± 0,2 mm, donde se observó un ligero aumento de la resistencia comparado con fosfatos comerciales.

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Listar por tema "Bioceramics"

In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics

Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition

Síntesis en estado sólido y caracterización de fosfato tricálcico dopado con magnesio y zinc

Envíos recientes

In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics

Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition

Síntesis en estado sólido y caracterización de fosfato tricálcico dopado con magnesio y zinc

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Listar por tema "Bioceramics"

In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics ﻿

Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition ﻿

Síntesis en estado sólido y caracterización de fosfato tricálcico dopado con magnesio y zinc ﻿

Envíos recientes

In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics

Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition

Síntesis en estado sólido y caracterización de fosfato tricálcico dopado con magnesio y zinc

Portales Institucionales

In vitro study of the proliferation and growth of human fetal osteoblasts on Mg and Si co-substituted tricalcium phosphate ceramics

Processing and in vitro bioactivity of a β-Ca3(PO4)2-CaMg(SiO3)2 ceramic with the eutectic composition

Síntesis en estado sólido y caracterización de fosfato tricálcico dopado con magnesio y zinc