TY - NEWS
TI - Alarmin’ immunologists: IL-33 as a putative target for modulating T cell-dependent responses
AU - YANEZ MENESES, LUZ FRANCY
AU - Gajardo Carrasco, Tania Fernanda
AU - Pérez Béssolo, Francisco Andrés
AU - Terraza-Aguirre, Claudia
AU - Campos-Mora, Mauricio
AU - Pino Lagos, Karina
AB - IL-33 is a known member of the IL-1 cytokine superfamily classically named “atypical” due to its diverse functions. The receptor for this cytokine is the ST2 chain (or IL-1RL1), part of the IL-1R family, and the accessory chain IL-1R. ST2 can be found as both soluble and membrane-bound forms, property that explains, at least in part, its wide range of functions. IL-33 has increasingly gained our attention as a potential target to modulate immune responses. At the beginning, it was known as one of the participants during the development of allergic states and other Th2-mediated responses and it is now accepted that IL-33 contributes to Th1-driven pathologies as demonstrated in animal models of experimental autoimmune encephalomyelitis (EAE), collagen-induced arthritis, and trinitrobenzene sulfonic acid-induced experimental colitis, among others. Interestingly, current data are placing IL-33 as a novel regulator of immune tolerance by affecting regulatory T cells (Tregs); although the mechanism is not fully understood, it seems that dendritic cells and myeloid suppressor-derived cells may be cooperating in the generation and/or establishment of IL-33-mediated tolerance. Here, we review the most updated literature on IL-33, its role on T cell biology, and its impact in immune tolerance.
DA - 2015-06-02
KW - iL-33
KW - T cells
KW - tolerance
KW - Transplantation
PB - Frontiers in Immunology
UR - https://repositorio.ufps.edu.co/handle/ufps/6433
ER -