@ARTICLE{YAN_Ala_2015,
author = "YANEZ MENESES, LUZ FRANCY - Gajardo Carrasco, Tania Fernanda - Pérez Béssolo, Francisco Andrés - Terraza-Aguirre, Claudia - Campos-Mora, Mauricio - Pino Lagos, Karina",
title = "Alarmin’ immunologists: IL-33 as a putative target for modulating T cell-dependent responses",
abstract = "IL-33 is a known member of the IL-1 cytokine superfamily classically named “atypical” due to its diverse functions. The receptor for this cytokine is the ST2 chain (or IL-1RL1), part of the IL-1R family, and the accessory chain IL-1R. ST2 can be found as both soluble and membrane-bound forms, property that explains, at least in part, its wide range of functions. IL-33 has increasingly gained our attention as a potential target to modulate immune responses. At the beginning, it was known as one of the participants during the development of allergic states and other Th2-mediated responses and it is now accepted that IL-33 contributes to Th1-driven pathologies as demonstrated in animal models of experimental autoimmune encephalomyelitis (EAE), collagen-induced arthritis, and trinitrobenzene sulfonic acid-induced experimental colitis, among others. Interestingly, current data are placing IL-33 as a novel regulator of immune tolerance by affecting regulatory T cells (Tregs); although the mechanism is not fully understood, it seems that dendritic cells and myeloid suppressor-derived cells may be cooperating in the generation and/or establishment of IL-33-mediated tolerance. Here, we review the most updated literature on IL-33, its role on T cell biology, and its impact in immune tolerance.",
year = 2015,
publisher = "Frontiers in Immunology",
url = "https://repositorio.ufps.edu.co/handle/ufps/6433",
}