TY - NEWS
TI - Simulating of Microbial Growth Scale Up in a Stirred Tank Bioreactor for Aerobic Processes using Computational Fluid Dynamics
AU - Gelves, German
AU - Niño, Lilibeth
AU - Hernandez, S
AB - In this paper, the effects of some empirical scale up criteria (Reynold´s number
and Impeller power per bioreactor volume) on gas-liquid mass transfer and microbial growth
rates are analyzed using computational fluid dynamics simulations in a stirred tank
bioreactor. The effects of turbulence, fluid flow and bubbles dynamics were simulated by
using a two equation turbulence model, a multiple reference frame and a population balance,
respectively. The impeller power per bioreactor volume scale up criterion showed better
microbial growth rates than Reynold´s number scale up criterion. However, high cellular
damage due to turbulence in animal cell culturing are still challenges in large scale up
bioreactor prototyping.
DA - 2020-11-04
PB - Journal of Physics: Conference Series
UR - https://repositorio.ufps.edu.co/handle/ufps/1496
ER -