TY - NEWS
TI - Industrial Scale Bioprocess Simulation for Ganoderma Lucidum Production using Superpro Designer
AU - Gelves, German
AU - Niño, Lilibeth
AU - Araque, J
AB - The medicinal mushroom Ganoderma lucidum is used by traditional medicine for
human infection treatments such as gastric cancer, hypertension, hepatitis, chronic bronchitis
and hypocholesterolemia. However, the conventional production of Ganoderma in a solid
phase on a large scale is costly and requires excessive processing times, which hinders its
technical-economic viability. Based on the preceding, engineering studies are needed to predict
their large-scale production, to identify the necessary industrial equipment and costs to propose
strategies that reduce operating costs. The SuperPro Designer computational tool is a very
versatile simulator used in a wide variety of industrial applications. That is why the purpose of
this research is to evaluate the production of the Ganoderma lucidum fungus in large-scale
growth culture from a computational approach. The latter, by performing simulations using
SuperPro Designer software to identify process yields and propose improvements aimed at
increasing productivity. The software was calibrated with experimental data reported from
literature and different strategies were intended to determine the economic viability. It was
found that the volume of the bioreactor significantly affects production costs compared to
exopolysaccharides yields, obtaining values of 6.82 USD/g in a 2 m3
bioreactor while in a
production volume of 20 m3
the costs are significantly reduced to 0.8 USD/g. The findings
found here demonstrate the importance of predicting a large-scale bioprocess to improve the
overall productivity of a biotechnological product.
DA - 2020-11-04
PB - Journal of Physics: Conference Series
UR - https://repositorio.ufps.edu.co/handle/ufps/1499
ER -