@ARTICLE{Con_A S_2021,
author = "Contreras Ropero, Jefferson Eduardo - Ruiz Roa, Silvia Liliana - García-Martinez, Janet - Urbina-Suarez, Nestor Andres - López Barrera, German Luciano - Barajas Solano, andres F - ZUORRO, Antonio",
title = "A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Preliminary Study for the Region of Norte de Santander (Colombia)",
abstract = "The production of vaccines of biological origin presents a tremendous challenge for researchers. In this context, animal cell cultures are an excellent alternative for the isolation and
production of biologicals against several viruses, since they have an affinity with viruses and a great
capacity for their replicability. Different variables have been studied to know the system’s ideal parameters, allowing it to obtain profitable and competitive products. Consequently, this work focuses
its efforts on evaluating an alternative for producing an anti-influenza biological from MDCK cells
using SuperPro Designer v8.0 software. The process uses the DMEN culture medium supplemented
with nutrients as raw material for cell development; the MDCK cells were obtained from a potential
scale-up with a final working volume of 500 L, four days of residence time, inoculum volume of
10%, and continuous working mode with up to a total of 7400 h/Yr of work. The scheme has the
necessary equipment for the vaccine’s production, infection, and manufacture with yields of up to
416,698 units/h. In addition, it was estimated to be economically viable to produce recombinant
vaccines with competitive prices of up to 0.31 USD/unit.",
year = 2021,
publisher = "Applied Sciences (Switzerland)",
url = "https://repositorio.ufps.edu.co/handle/ufps/6933",
}